Which of the following is NOT an expected effect of the binding of the glucocorticoid response element by GR?
A) upregulation of annexin I
B) inhibition of the inflammatory response
C) upregulation of cyclooxygenase-2
D) decreased interaction of p65 and p50 of NF$\kappa$B

Question

Quizplus · Accepted Answer

The upregulation of cyclooxygenase-2 is not an expected effect of the binding of the glucocorticoid response element by GR. GR binding generally leads to inhibition of the inflammatory response, upregulation of anti-inflammatory proteins like annexin I, and decreased interaction of p65 and p50 subunits of the transcription factor NF-κB.

Which of the Following Is NOT an Expected Effect of the Binding