The __________ domain functions as a protein-protein interaction module and is located in the cytoplasmic tail of TNF receptors.
A) death
B) SH2
C) SH3
D) RIP

Question

Quizplus · Accepted Answer

The death domain is the protein-protein interaction module located in the cytoplasmic tail of TNF receptors. It is named as the death domain because it mediates many of the signaling pathways that result in programmed cell death. SH2 and SH3 domains are protein domains found in signaling proteins that mediate intracellular signaling by binding to specific phosphotyrosine residues or proline-rich motifs, respectively. RIP (receptor interacting protein) is a protein involved in the regulation of cell death and inflammation.

The __________ Domain Functions as a Protein-Protein Interaction Module and Is