The glutamate side chain in the active site of HMG-CoA reductase acts as a general base only after A) the mevalonate binds to the active site. B) the hydride from the second NADPH attacks the carbonyl center of the aldehyde. C) a conformational change triggers the exchange of NADP⁺for NADPH. D) CoA is reduced to CoA-SH.

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Quizplus · Accepted Answer

The Answer of The glutamate side chain in the active site of HMG-CoA reductase acts as a general base only after A) the mevalonate binds to the active site. B) the hydride from the second NADPH attacks the carbonyl center of the aldehyde. C) a conformational change triggers the exchange of NADP⁺for NADPH. D) CoA is reduced to CoA-SH.

The Glutamate Side Chain in the Active Site of HMG-CoA