The mutation that would lead to the most dramatic effect on Ca²⁺transport is a mutation of A) Ser16 in phospholamban. B) Thr17 in phospholamban. C) Asp351 in SERCA. D) Ser17 in E2P.

Question

Quizplus · Accepted Answer

Asp351 in SERCA is crucial for the binding and release of Ca2+ ions during transport. Mutations in this residue can severely impair the overall function of SERCA and disrupt the Ca2+ transport. Therefore, a mutation in Asp351 would have the most dramatic effect on Ca²⁺ transport. Mutations in the other residues listed may also affect Ca2+ transport, but not to the same extent as a mutation in Asp351.

The Mutation That Would Lead to the Most Dramatic Effect