Which gives rise to a favorable enthalpic ($\Delta$S) driving force for protein folding?
A) The lining up of hydrogen bonds as the protein folds.
B) The limiting of possible conformations as the protein folds.
C) The decrease in ordered water molecules as hydrophobic amino acids pack together.
D) The stabilization caused by favorable electrostatic interactions of amino acid side chains.

Question

Quizplus · Accepted Answer

As hydrophobic amino acids pack together, there is a decrease in the ordered water molecules surrounding these non-polar residues. This disruption in the hydrogen bonding network of water molecules leads to an entropy decrease (ΔS<0) which results in a favorable enthalpic (ΔH<0) driving force for protein folding. This phenomenon is known as the hydrophobic effect.

Which Gives Rise to a Favorable Enthalpic Δ\DeltaΔ S) Driving Force for Protein Folding? A) the Lining Up

Which Gives Rise to a Favorable Enthalpic $\Delta$ S) Driving Force for Protein Folding?
A) the Lining Up