Considering the overall human population of the U.S.mainland at the time when the slave trade brought large numbers of people from equatorial Africa,what was primarily acting to change the frequency of the sickle-cell allele in the overall U.S.population?

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Gene flow was primarily acting to change the frequency of the sickle-cell allele in the overall U.S. population due to the introduction of individuals from equatorial Africa, where the allele is more common, into the U.S. population through the slave trade. This movement of people and their genes into a new population is a classic example of gene flow.

Considering the Overall Human Population of the U