The frequency of heterozygosity for the sickle-cell anemia allele is unusually high,presumably because this reduces the frequency of malaria.Such a relationship is related to which of the following concepts?

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This relationship is related to Darwin's explanation of natural selection because the high frequency of heterozygosity for the sickle-cell anemia allele is advantageous in areas with a high prevalence of malaria. Individuals with the sickle-cell trait have an increased resistance to malaria, and therefore, are more likely to survive and pass on their genes to the next generation. Over time, this can result in an increase in the frequency of the sickle-cell allele in populations living in malaria-endemic regions.

The Frequency of Heterozygosity for the Sickle-Cell Anemia Allele Is