The two biggest issues that hampered Van Buren's bid for reelection were financial problems and the annexation of Texas.

Name: The two biggest issues that hampered Van Buren's bid for reelection were financial problems and the annexation of Texas.
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Van Buren faced the Panic of 1837, which caused a major economic depression, and his opposition to the annexation of Texas led to divisions within his party, ultimately contributing to his defeat in the election of 1840.

The Two Biggest Issues That Hampered Van Buren's Bid for Reelection