All drugs of abuse affect dopamine levels in the same manner by directly facilitating release from the presynaptic neuron and increasing levels in the synapse.

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Quizplus · Accepted Answer

While many drugs of abuse do increase dopamine levels by facilitating release from the presynaptic neuron, they do not all do so in the same manner. For example, some drugs (such as cocaine) block the reuptake of dopamine by the presynaptic neuron, leading to increased levels in the synapse. Other drugs (such as opioids) indirectly affect dopamine levels by decreasing the activity of inhibitory neurons that normally dampen dopamine release.

All Drugs of Abuse Affect Dopamine Levels in the Same