If simultaneous administration of an agonist and antagonist cause a downward shift in the maximal effect of an agonist's response,the antagonist would be considered:

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Quizplus · Accepted Answer

If simultaneous administration of an agonist and antagonist cause a downward shift in the maximal effect of an agonist's response, then the antagonist is considered noncompetitive. This is because a noncompetitive antagonist binds to a different site on the receptor than the agonist and can bind irreversibly, reducing the maximal effect of the agonist's response. Competitive antagonists compete with the agonist for the same binding site and can be overcome by increasing the concentration of the agonist. Allosteric modulators bind to a different site on the receptor than the agonist and can either enhance or reduce the response to the agonist. Reversible antagonists can bind to the same site as the agonist but can be displaced by increasing the concentration of the agonist.

If Simultaneous Administration of an Agonist and Antagonist Cause a Downward