The reduction in the number or sensitivity of receptors in response to prolonged activation by a drug is termed:

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Down regulation is the process in which the number or sensitivity of receptors decrease in response to prolonged activation by a drug. This reduces the drug's effectiveness and is a form of tolerance. Metabolic tolerance is a form of tolerance in which the body becomes more efficient at metabolizing the drug, reducing its duration and intensity of action. Homeostasis refers to the tendency of the body to maintain a stable internal environment, including drug levels. Physical dependence is a state in which the body adapts to the presence of a drug and experiences withdrawal symptoms upon cessation of use.

The Reduction in the Number or Sensitivity of Receptors in Response