Widely used prior to levodopa,______ are now considered to be be second-tier agents for the treatment of Parkinson's disease.

Question

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Muscarinic receptor antagonists, also known as anticholinergics, were commonly used before the discovery of levodopa. However, due to their significant side effects (such as dry mouth, blurred vision, constipation, and cognitive impairment) and the availability of more effective treatments, they are now considered second-tier agents for the treatment of Parkinson's disease.

Widely Used Prior to Levodopa,______ Are Now Considered to Be