The major mechanism of action of lamotrigine (Lamictal)is blockade of voltage-gated Na⁺ channels.

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Lamotrigine (Lamictal) is an anti-epileptic drug that blocks voltage-gated Na+ channels, specifically NaV1.1, NaV1.2, and NaV1.6. It also modulates voltage-gated Ca2+ channels and inhibits glutamate release. However, its primary mechanism of action is thought to be blockade of Na+ channels, leading to stabilization of neuronal membranes and reduction of excessive synaptic excitation.

The Major Mechanism of Action of Lamotrigine (Lamictal)is Blockade of Voltage-Gated