Tramadol (Ultram)can increase the toxicity of 5-HT-based antidepressants.

Question

Quizplus · Accepted Answer

Tramadol (Ultram) has the potential to increase the toxicity of 5-HT-based antidepressants, such as SSRIs (selective serotonin reuptake inhibitors), SNRIs (serotonin-norepinephrine reuptake inhibitors), and MAOIs (monoamine oxidase inhibitors). This is due to the fact that both tramadol and these antidepressants increase levels of serotonin in the brain, which can lead to a potentially dangerous condition known as serotonin syndrome. Patients taking both tramadol and 5-HT-based antidepressants should be closely monitored for signs of serotonin syndrome, such as agitation, fever, muscle rigidity, and seizures.

Tramadol (Ultram)can Increase the Toxicity of 5-HT-Based Antidepressants