The Client Has Had Hypertension for Many Years

The client has had hypertension for many years. The physician orders a antihypertensive drug that has just come on the market. The nurse teaches the client that this drug works more effectively than his prior drug, and has fewer side effects. The client asks how this can be. What is the best response by the nurse? Select all that apply.

A) "Receptors tend to "burn -out", so newer drugs are required."
B) "Changing the response of the drug to protein receptor -complexes produces fewer side effects."
C) "It is a process of trial and error with receptors until the new drug proves effective."
D) "Research into receptors helps "fine -tune" drugs to be more effective."
E) "Newer drugs are altered to affect your cells' receptors in a different way."