The client is receiving atorvastatin (Lipitor). Which new medication order would the nurse validate with the physician?

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Atorvastatin is metabolized by the CYP3A4 enzyme, and ketoconazole is a potent inhibitor of this enzyme. Co-administration of atorvastatin and ketoconazole can increase the levels of atorvastatin in the body, leading to an increased risk of adverse effects such as muscle damage. Therefore, the nurse should validate the order of ketoconazole with the physician before administering it to the client taking atorvastatin. Pioglitazone, fluoxetine, and propranolol do not have significant interactions with atorvastatin, and their administration would not require validation with the physician in this case.

The Client Is Receiving Atorvastatin (Lipitor)