An opiate "designer drug" that has been shown to produce Parkinson's-like symptoms in users is .

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MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is a synthetic compound that produces Parkinson's-like symptoms in users. It was accidentally discovered that MPTP caused parkinsonism in drug users who consumed a contaminated batch of a synthetic opioid. MPTP selectively destroys dopamine-producing neurons in the substantia nigra, leading to a decrease in dopamine levels in the brain, which is a hallmark of Parkinson's disease. Ecstasy, ice, and crank are synthetic drugs that do not produce Parkinson's-like symptoms.

An Opiate "Designer Drug" That Has Been Shown to Produce