Eukaryotic cells have their DNA molecules inside their nuclei.However, to package all the DNA into such a small volume requires the cell to use specialized proteins called histones.Histones have amino acid sequences enriched for lysines and arginines.
A.What problem might a cell face in trying to package DNA into a small volume without histones, and how do these special packaging proteins alleviate the problem?
B.Lysine side chains are substrates for enzymes called acetylases.A diagram of an acetylated lysine side chain is shown in Figure 2-78.How do you think the acetylation of lysines in histone proteins will affect the ability of a histone to perform its role (refer to your answer in part A)? Figure 2-78

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The Answer of Eukaryotic cells have their DNA molecules inside their nuclei.However, to package all the DNA into such a small volume requires the cell to use specialized proteins called histones.Histones have amino acid sequences enriched for lysines and arginines.
A.What problem might a cell face in trying to package DNA into a small volume without histones, and how do these special packaging proteins alleviate the problem?
B.Lysine side chains are substrates for enzymes called acetylases.A diagram of an acetylated lysine side chain is shown in Figure 2-78.How do you think the acetylation of lysines in histone proteins will affect the ability of a histone to perform its role (refer to your answer in part A)? Figure 2-78

Eukaryotic Cells Have Their DNA Molecules Inside Their Nuclei