Enzymes generally make good drug targets because a specific reaction of interest can be targeted with a high degree of selectivity.Consider the following three drugs and explain why, although reaction-specific, the first two produce side effects, while the third does not.
A.Statins inhibit HMG CoA reductase to block intracellular cholesterol synthesis.
B.Methotrexate inhibits dihydrofolate reductase, which subsequently leads to blocked DNA replication.
C.Gleevec® inhibits BCR, a kinase that is only produced in certain types of leukemia cells.

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The Answer of Enzymes generally make good drug targets because a specific reaction of interest can be targeted with a high degree of selectivity.Consider the following three drugs and explain why, although reaction-specific, the first two produce side effects, while the third does not.
A.Statins inhibit HMG CoA reductase to block intracellular cholesterol synthesis.
B.Methotrexate inhibits dihydrofolate reductase, which subsequently leads to blocked DNA replication.
C.Gleevec® inhibits BCR, a kinase that is only produced in certain types of leukemia cells.

Enzymes Generally Make Good Drug Targets Because a Specific Reaction