The core histones are small, basic proteins that have a globular domain at the C-terminus and a long, extended conformation at the N-terminus.Which of the following is NOT true of the N-terminal "tail" of these histones?

Question

Quizplus · Accepted Answer

The N-terminal tail of histones is not specific to binding DNA in a sequence-specific manner. Rather, it interacts with DNA non-specifically and helps to pack the DNA tightly into the nucleosome core. The tail is subject to various post-translational modifications, such as acetylation, methylation, and phosphorylation, which can affect gene expression and other DNA-related processes. The N-terminal tail also extends out of the nucleosome core, allowing for interactions with other proteins involved in chromatin organization and gene regulation.

The Core Histones Are Small, Basic Proteins That Have a Globular