Which of the Following Changes Is Least Likely to Arise

Which of the following changes is least likely to arise from a point mutation in a regulatory region of a gene?

A) A mutation that changes the time in an organism's life during which a protein is expressed.
B) A mutation that eliminates the production of a protein in a specific cell type.
C) A mutation that changes the subcellular localization of a protein.
D) A mutation that increases the level of protein production in a cell.