In step 4 of the citric acid cycle, the reduction of NAD⁺ to NADH is coupled to the generation of CO₂ and the formation of a high-energy thioester bond.Which molecule provides the sulfhydryl group necessary to form the thioester bond?

Question

Quizplus · Accepted Answer

The molecule that provides the sulfhydryl group necessary to form the thioester bond is CoA. CoA contains a thiol (-SH) group on its terminal end, which is used to form a high-energy thioester bond with the acetyl group. This thioester bond stores energy that can be used in subsequent reactions.

In Step 4 of the Citric Acid Cycle, the Reduction