The following happens when a G-protein-coupled receptor activates a G protein.

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When a G-protein-coupled receptor activates a G protein, the α subunit exchanges its bound GDP for GTP. This activates the α subunit, allowing it to interact with downstream effector proteins, while the βγ complex remains associated and may also interact with effectors. The exchange of GDP for GTP on the α subunit is facilitated by the binding of the receptor to the G protein, causing a conformational change that promotes GDP release and GTP binding.

The Following Happens When a G-Protein-Coupled Receptor Activates a G