The growth factor RGF stimulates proliferation of cultured rat cells.The receptor that binds RGF is a receptor tyrosine kinase called RGFR.Which of the following types of alteration would be most likely to prevent receptor dimerization?

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Quizplus · Accepted Answer

A mutation that prevents RGFR from binding to RGF would most likely prevent receptor dimerization because the binding of the ligand (RGF) to its receptor (RGFR) is typically a crucial first step in receptor dimerization and subsequent activation of the signaling pathway. Without the ability to bind its ligand, the receptor cannot undergo the conformational changes necessary for dimerization.

The Growth Factor RGF Stimulates Proliferation of Cultured Rat Cells