You create cells with a version of the origin recognition complex, ORC, that cannot be phosphorylated by S-Cdk and thus cannot be inactivated.Which of the following statements describes the likely consequence of this change in ORC?

Question

Quizplus · Accepted Answer

Phosphorylation of ORC by S-Cdk inactivates it and prevents it from binding to DNA, ensuring that the genome is replicated only once per cell cycle. If ORC cannot be phosphorylated, it will remain active and bind to DNA even in the presence of S-Cdk. This could lead to replication of some regions of the genome more than once in a cell cycle, known as re-replication, and can be detrimental to the cell.

You Create Cells with a Version of the Origin Recognition