A disease which occurs most commonly in women, with onset between the ages of 20 and 50, and characterized by destruction of joint surfaces, joint capsule, and ligaments causing marked deformity and joint instability is

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The description best fits rheumatoid arthritis, which is a systemic autoimmune disease that causes chronic inflammation of the joints leading to pain, stiffness, and deformity. Osteoarthritis is more commonly associated with aging and wear-and-tear on the joints, while Dupuytren contracture and tenosynovitis are specific conditions that affect the hand and wrist. "Rheumatism" is a general term that is no longer used to describe a specific disease, but rather any disorder that affects the joints, muscles, or connective tissues.

A Disease Which Occurs Most Commonly in Women, with Onset