The ozone hole over Antarctica and the general lowering of ozone levels elsewhere in the stratosphere have been attributed to the ozone-destroying properties of:

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Chlorofluorocarbons (CFCs) are synthetic chemicals that were used in refrigerators, air conditioners, aerosol sprays, and other products, until they were phased out under the Montreal Protocol in 1987. CFCs are chemically stable and have the ability to rise into the stratosphere, where they release chlorine atoms that can catalyze the breakdown of ozone molecules. As a result, the ozone layer thins and an ozone hole forms over Antarctica during the South Pole's spring.

The Ozone Hole Over Antarctica and the General Lowering of Ozone