One method of protecting the genetic isolation of a population is the inability of sperm to fertilize eggs of a different species. This is called:

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Gametic incompatibility refers to the inability of the sperm from one species to fertilize the eggs of another species, and is a form of prezygotic reproductive isolation that helps maintain genetic isolation of populations. Ecological isolation involves species occupying different habitats, temporal isolation involves species reproducing at different times, and behavioral isolation involves species having different courtship behaviors or mate preferences. Hybrid inviability refers to the reduced fitness or inability of hybrid offspring to survive and reproduce.

One Method of Protecting the Genetic Isolation of a Population