Which Statement About Penicillins Is INCORRECT

Which statement about penicillins is INCORRECT?

A) Penicillins + β-lactamase inhibitor is a combination of agents that protects the penicillin against enzymatic digestion.
B) Broad-spectrum penicillins are active against penicillin-sensitive Gram-positive bacteria and also many Gram-negative bacteria.
C) Some S. aureus strains have the ability to make altered penicillin binding proteins to which most β-lactam antibiotics do not bind as well.
D) The penicillins produced naturally by the mold P. chrysogenum are broad-spectrum, effective against all Gram-positive and many Gram-negative bacteria.
E) Bacteria that produce penicillinase are resistant to the natural penicillins.