The rates of change in the human lineage for highly accelerated regions of the genome that have undergone negative selection imply that they have been shaped by

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Highly accelerated regions of the genome that have undergone negative selection (i.e., purifying selection) are unlikely to be shaped by genetic drift or mutation alone. Instead, their rapid evolution likely reflects the action of natural selection against deleterious mutations, which can arise spontaneously through errors in DNA replication or other cellular processes. Sexual selection, which refers to the differential mating success of individuals due to traits that enhance their attractiveness or competitive ability, is unlikely to play a major role in shaping highly accelerated regions of the genome that are subject to negative selection.

The Rates of Change in the Human Lineage for Highly