The recessive allele for sickle cell anemia is more prevalent in regions of Africa where malaria is prevalent,than it is in regions where there is no malaria.This is due to

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The heterozygous advantage occurs when individuals with one copy of the sickle cell allele (heterozygotes) have a survival advantage in malaria-prone regions because they are more resistant to malaria compared to individuals with normal hemoglobin. This maintains the prevalence of the sickle cell allele in these populations.

The Recessive Allele for Sickle Cell Anemia Is More Prevalent