If a Reaction Is Second-Order with Respect to a Particular $\frac { 1 } { 16 }$

If a reaction is second-order with respect to a particular reactant, when the concentration of that reactant is increased by a factor of 4, the reaction rate will _____.

A) increase by a factor of 16.
B) remain constant.
C) decrease by a factor of $\frac { 1 } { 16 }$ .
D) increase by a factor of 64.
E) decrease by a factor of $\frac { 1 } { 4 }$ .