Diuretic Resistance After Chronic Loop Diuretic Administration Is Due To

Diuretic resistance after chronic loop diuretic administration is due to:

A) Increase in the transport of organic cations from the blood to the urine
B) Increased Na⁺/K⁺ -ATPase activity
C) A decrease in Na⁺ reabsorption by distal tubule cells
D) Decreased osmotic load at the distal tubule
E) Decreased Na⁺/K⁺ -ATPase activity