Which of the Following Best Describes Where the Amino Acids

Which of the following best describes where the amino acids isoleucine and tryptophan are most likely to be found in the tertiary structure of a protein?

A) at the N-terminal end of the protein
B) at the C-terminal end of the protein
C) on the exterior surface of the folded protein where contact with water is greatest, due to their hydrophilic nature
D) in the interior of the folded protein away from water, due to their hydrophobic nature
E) in the hydrophilic interior of the protein due to their ability to form side chain hydrogen bonds with each other