Hypogammaglobulinemia is a significant feature in half of patients with CLL.This complication can lead to:

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Hypogammaglobulinemia in CLL patients can lead to increased susceptibility to infections due to the decreased production of immunoglobulins. Autoimmune hemolytic anemia (AIHA) is a known complication of CLL, where the immune system mistakenly attacks and destroys red blood cells, leading to anemia. This is not directly caused by hypogammaglobulinemia but is related to the underlying immune dysregulation in CLL.

Hypogammaglobulinemia Is a Significant Feature in Half of Patients with CLL.This