In patients with sickle cell trait and no complicating disease:

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In patients with sickle cell trait, the red blood cells generally appear normal under most conditions, and there is no severe anemia or a significant decrease in hemoglobin, hematocrit, or RBC count. However, these individuals may experience occasional hematuria due to sickling in the renal medulla, which can affect the renal papillae and lead to blood in the urine. Sickle cells are not prevalent in the peripheral blood, and findings such as NRBCs (nucleated red blood cells) and polychromasia are not typical in the absence of a complicating disease.

In Patients with Sickle Cell Trait and No Complicating Disease