Spherocytes may enter the circulation via a variety of mechanisms.To distinguish the CBC of a patient with hereditary spherocytosis from the CBC of a patient with autoimmune hemolytic anemia, one could use the:

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The MCHC (mean corpuscular hemoglobin concentration) is typically elevated in hereditary spherocytosis due to the reduced cell volume of spherocytes, which concentrates the hemoglobin. In contrast, MCHC may not be significantly altered in autoimmune hemolytic anemia. This makes MCHC a useful parameter to distinguish between the two conditions.

Spherocytes May Enter the Circulation Via a Variety of Mechanisms