Which mechanism accounts for the reaction of chlorobenzene with acetyl chloride and AlCl₃ to form 4-chloroacetophenone? A) Bimolecular nucleophilic substitution (S_N2) B) Nucleophilic aromatic substitution by elimination-addition C) Nucleophilic aromatic substitution by addition-elimination D) Electrophilic aromatic substitution

Question

Quizplus · Accepted Answer

Electrophilic aromatic substitution is the mechanism that accounts for the reaction of chlorobenzene with acetyl chloride in the presence of AlCl3 to form 4-chloroacetophenone. In this process, the AlCl3 acts as a Lewis acid catalyst, facilitating the formation of an acylium ion from acetyl chloride, which then acts as the electrophile in the substitution reaction on the aromatic ring of chlorobenzene.

Which Mechanism Accounts for the Reaction of Chlorobenzene with Acetyl