Which of the following is the correct order of decreasing reactivity in hydrolysis reactions (more reactive less reactive)?
A) anhydrides amides acid chlorides
B) amides acid chlorides anhydrides
C) anhydrides acid chlorides amides
D) acid chlorides anhydrides amides

Question

Which of the following is the correct order of decreasing reactivity in hydrolysis reactions (more reactive > less reactive)?
A) anhydrides > amides > acid chlorides
B) amides > acid chlorides > anhydrides
C) anhydrides > acid chlorides > amides
D) acid chlorides > anhydrides > amides

Quizplus · Accepted Answer

The correct order of decreasing reactivity in hydrolysis reactions is acid chlorides > anhydrides > amides. Acid chlorides are the most reactive due to the high electrophilicity of the carbonyl carbon, making them more susceptible to nucleophilic attack. Anhydrides come next, being less reactive than acid chlorides but more reactive than amides. Amides are the least reactive in this series due to the strong resonance stabilization of the amide bond, which makes them less electrophilic.

Which of the Following Is the Correct Order of Decreasing