How Are RBC Levels Affected by Chronic Renal Failure

How are RBC levels affected by chronic renal failure?

A) Erythropoietin production is reduced and the toxic waste accumulation suppresses bone marrow's ability to produce RBCs
B) The electrolyte abnormalities breakdown the RBCs and cause anemia
C) The renal acidemia breaks down the RBCs and the fragments impair the bone marrow's ability to produce new RBCs
D) The level of erythropoietin level is stimulated from the chronic hypoxemia so polycythemia results