Which of these European imports to the Americas had the most negative impact on Native Americans?

Question

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Livestock introduced by Europeans, such as pigs and cattle, had a significant negative impact on Native American populations. These animals often destroyed the native plants that Indigenous peoples relied on for food and medicine, altering ecosystems. Additionally, livestock brought over by Europeans were carriers of diseases to which Native Americans had no immunity, leading to devastating epidemics.

Which of These European Imports to the Americas Had the Most