When large numbers of RBCs break down in the circulation, the urine can turn reddish or brown in a condition called

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Hemoglobinuria occurs when large numbers of RBCs break down in the circulation and release their hemoglobin into the urine, causing it to turn reddish or brown in color. Sickle cell anemia, pernicious anemia, leucopenia, and septicemia do not necessarily cause hemoglobin to be released into the urine.

When Large Numbers of RBCs Break Down in the Circulation