Wayne tends to suffer from chronic pessimism, is hypersensitive to rejection, worries obsessively, and is prone to sudden bursts of irrational anger. He is exhibiting the symptoms of

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Serotonin depletion is associated with mood disorders, including increased irritability, depression, and anxiety, which align with Wayne's symptoms of chronic pessimism, hypersensitivity to rejection, obsessive worrying, and irrational anger.

Wayne Tends to Suffer from Chronic Pessimism, Is Hypersensitive to Rejection