The sickle-cell anemia allele, S, experiences strong negative selection because of its deleterious effect on homozygotes, yet the allele is maintained at frequencies higher than expected because having only one copy can increase survival in areas where malaria is prevalent. This is an example of

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The sickle-cell anemia allele is an example of heterozygote advantage because individuals with one copy of the allele (heterozygotes) have increased survival in malaria-prevalent areas compared to individuals with two copies or no copies of the allele. This is also an example of balancing selection, where genetic diversity is maintained in a population by selection for the heterozygote.

The Sickle-Cell Anemia Allele, S, Experiences Strong Negative Selection Because