Extrinsic postzygotic isolation is most likely when

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Extrinsic postzygotic isolation occurs when offspring resulting from the mating of individuals from two different populations are less fit because they inherit a combination of genes that is not well-suited to either parent's environment. This is most likely when the parental populations are adapted to divergent environments, as the hybrid offspring may not be well adapted to either environment, leading to reduced survival or reproductive success.

Extrinsic Postzygotic Isolation Is Most Likely When