What event led Europeans to look toward Africa as a primary source of slaves?

Question

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The fall of Constantinople in 1453 was a pivotal event that led Europeans to look toward Africa as a primary source of slaves. The fall of this key city to the Ottoman Turks disrupted traditional trade routes, including those for slaves from Eastern Europe and Central Asia, prompting Europeans to seek new sources of labor for their emerging Atlantic economies.

What Event Led Europeans to Look Toward Africa as a Primary