What Is the Role of the Enzyme IKK in Cellular $\kappa$

What is the role of the enzyme IKK in cellular antiviral defenses?

A) It phosphorylates the Stat protein during interferon signaling.
B) It phosphorylates IRF-3 transcription factor and activates it.
C) It phosphorylates the NF- $\kappa$ B protein and activates it.
D) It phosphorylates the IkB protein and inactivates it.
E) It phosphorylates the IkB protein and activates it.