Which of the Following Can Induce the Extrinsic Apoptosis Pathway $\alpha$

Which of the following can induce the extrinsic apoptosis pathway?

A) Direct damage to cellular DNA.
B) Binding of TNF $\alpha$ to the a cell surface receptor.
C) Increased activity of the p53 protein.
D) Release of cytochrome c from the mitochondria.
E) Activation of the cytoplasmic caspase enzymes.