The cultured human cell line HeLa expresses the E6 and E7 proteins of human papillomavirus.What would happen to these cells if the expression of these proteins was shut off?

Question

Quizplus · Accepted Answer

The E6 and E7 proteins of human papillomavirus are known to inactivate tumor suppressor proteins like p53 and Rb, allowing the cells to bypass normal cell cycle checkpoints and avoid apoptosis. If the expression of these proteins is shut off, the cells would likely undergo apoptosis due to the reactivation of these tumor suppressor pathways.

The Cultured Human Cell Line HeLa Expresses the E6 and E7