The yellow fever vaccine strain has 32 amino acid mutations in comparison to the wildtype pathogenic virus strain.Which of the following genes contains the majority of these amino acid substitutions?

Question

Quizplus · Accepted Answer

The envelope glycoprotein is the most important target for neutralizing antibodies in yellow fever virus infection and is responsible for viral attachment to host cells. The amino acid substitutions in the yellow fever vaccine strain are believed to be responsible for the attenuation of the virus and its ability to cause disease. Therefore, it is likely that the majority of these substitutions are located in the envelope glycoprotein gene.

The Yellow Fever Vaccine Strain Has 32 Amino Acid Mutations